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Proc Natl Acad Sci U S A 107: 74557460, 2010 [DOI] [PMC free article] [PubMed] [Google Scholar] 37

Specifically, hepatoma cells with low expression of GOT2 showed a high dependence on Gln metabolism by increasing Gln metabolism, nucleotide synthesis, and glutathione synthesis to support cellular antioxidants (Fig